Can Testosterone Cypionate Injections be done subcutaneously (sub-Q)? – Boston Testosterone Partners

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The question gets asked by many men when they begin testosterone therapy with BTP.  The answer is yes!   The risk is always in forming an abscess, but in our experience, using .5 mls of less per sub-Q shot leaves very little risk of that.

While intramuscular injections are the preferred manner of administration, sub-Q shots are gaining popularity among men across the country who restore their testosterone.

Contact Boston Testosterone Partners for more information on our Testosterone Replacement Therapies and Preventative Medicines.

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STUDY 1

Saudi Med J. 2006 Dec;27(12):1843-6.

Subcutaneous administration of testosterone. A pilot study report.

Al-Futaisi AMAl-Zakwani ISAlmahrezi AMMorris D.
Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman. alfutaisi@squ.edu.om

Abstract

OBJECTIVE: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients.

METHODS: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Monteral, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using 0.5 ml insulin syringe.

RESULTS: A total of 22 patients were enrolled in the study. The mean trough was 14.48 +/- 3.14 nmol/L and peak total testosterone was 21.65 +/- 7.32 nmol/L. For the free testosterone the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported.

CONCLUSION: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.

PMID: 17143361 [PubMed – indexed for MEDLINE]

 

STUDY 2:

STABLE TESTOSTERONE LEVELS ACHIEVED WITH SUBCUTANEOUS TESTOSTERONE INJECTIONS

M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada

Objectives: The preferred technique of androgen replacement has been intramuscular (IM) testosterone, but wide variations in testosterone levels are often seen. Subcutaneous (SC) testosterone injection is a novel approach; however, its physiological effects are unclear. We therefore investigated the sustainability of stable testosterone levels using SC therapy. Patients and methods: Between May and September 2005, we conducted a small pilot study involving 10 male patients with symptomatic late-onset hypogonadism.

Every patient had been stable on TE 200 mg IM for 1 year. Patients were instructed to self-inject with testosterone enanthate (TE) 100 mg SC (DELATESTRYL 200 mg/cc, Theramed Corp, Canada) into the anterior abdomen once weekly. Some patients were down-titrated to 50 mg based on their total testosterone (T) at 4 weeks.

Informed consent was obtained as SC testosterone administration is not officially approved by Health Canada. T levels were measured before and 24 hours after injection during weeks 1, 2, 3, and 4, and 96 hours after injection in week 6 and 8. 

At week 12, PSA, CBC, and T levels were measured however; the week 12 data are still being collected. 

Results: Prior to initiation of SC therapy, T was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit 0.47+0.02, and PSA 1.05+0.65 ng/ml. During the first 4 weeks, there was a steady increase in pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l (p¼0.1). However, after 8 weeks the post-injection T (25.77+7.67 nmol/l) remained similar to that of week 1 (27.46+12.91 nmol/l). Patients tolerated this therapy with no adverse effects. 

Conclusions: A once-week SC injection of 50-100 mg of TE appears to achieve sustainable and stable levels of physiological T. This technique offers fewer physician visits and the use of smaller quantity of medication, thus lower costs. However, the long term clinical and physiological effects of this therapy need further evaluation.

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Life or Death: Lethal Dangers of High Estrogen and Low Testosterone Levels.

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Boston Testosterone Partners

Boston, Massachusetts –

A study published in the Journal of the American Medical Association measured blood estradiol (a dominant estrogen) in 501 men with chronic heart failure. Compared to men in the balanced estrogen quintile, the men in the highest estradiol quintile were 133% more likely to die. These Men had serum estradiol levels of 37.40 pg/mL or above.

The men in the balanced quintile—with the fewest deaths—had serum estradiol levels between 21.80 and 30.11 pg/mL, the ideal range that we at Boston Testosterone Partners put our clients!

The dramatic increase in mortality in men with unbalanced estrogen (i.e., estradiol levels either too high or too low) is nothing short of astounding. It uncovers a gaping hole in conventional cardiology practice that is easily correctable.

Additionally, recent medical studies have also detailed the incidence of Prostate Cancers among males whose estradiol levels are high and whose testosterone levels are low.

Testosterone Replacement Therapy Doctors

Boston Testosterone Partners

We at Boston Testosterone Partners know how to put all our Male Clients in the Estrogen/Testosterone Optimal Ranges with our proprietary TRT protocols!!! Very few doctors today understand this important balance, we do.

Low Testosterone Predict Mortality in Aging Men

In a recent study of 3,014 men aged 69-80 years, serum levels of testosterone and estradiol were measured during a mean follow-up of 4.5 years. Men with low testosterone had 65% greater all-cause mortality, while men with low estradiol suffered 54% more deaths.

Those men low in estradiol and testosterone were almost twice as likely to die (a 96% increase in mortality) compared to men in the optimal ranges.

Another recent study in 2010 demonstrated that Low Testosterone is strongly associated with Cardiovascular Disease and an almost 50% increase in mortality over a seven year period!!!

These large studies of aged men corroborates prior published reports linking imbalances of testosterone and/or estradiol with greater incidences of degenerative disease and death.

Call today to regain control of your Health and Aging!!!

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855-617-MEDS (6337)

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Low Testosterone Levels linked to increases in death – Boston Testosterone Partners

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Boston Testosterone Partners

Boston Testosterone Partners

Boston, Massachusetts – Beginning at age 30, men’s testosterone begins to drop and , on average, testosterone levels drop by 1% or more a year so by age fifty your testosterone levels may be 50% of what they were at age 30.  Low testosterone is also referred to as low androgens, andropause, testosterone deficiency or low T.

Some of the common symptoms of low testosterone often include low libido, mood changes, insomnia, fatigue, loss of muscle mass and strength, bone loss, and weight gain.

A report published in the British journal Heart reveals an increased risk of early death from all causes and cardiovascular disease among men who had low testosterone levels.

Researchers in that study analyzed data from 930 already sick  men with cardiovascular disease who underwent elective coronary angiography in a cardiac referral center between 2000 and 2002.  Total testosterone and bioavailable testosterone were measured on the day of their procedure.

The subjects were followed for about 7 years.  129 deaths occurred over the 930 men during that time.  73 of the deaths were due to their related cardiovascular disease.  24 percent of the participants had either low total or bioavailable testosterone.

Results:  21 percent of those with deficient bioavailable testosterone levels died from all causes over follow-up, compared to 12 percent of those with normal levels.

Low bioavailable testosterone levels were also associated with an increased risk of dying of cardiovascular causes.  Moreover, borderline low levels of total testosterone were associated with an increased risk of dying over follow-up.

“Clinical studies of testosterone supplementation in men with low testosterone are associated with reduced visceral adiposity, improved insulin sensitivity and an improved metabolic profile. Studies in subjects with cardiovascular diseases also suggested beneficial effects, with improved functional capacity in heart failure and improved symptoms in subjects with coronary artery disease.” says Dr Ronald C. W. Ma and Peter C. Y. Tong of Chinese University of Hong Kong and Prince of Wales Hospital, as part of the study.

“Compared with research on estrogens and cardiovascular disease, the role of androgens in the pathogenesis of metabolic and cardiovascular diseases has taken a backseat for many years,” they note. “Recent data suggest that this important pathway warrants a lot more attention.”

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BOSTON, MASSACHUSETTS – BOSTON TESTOSTERONE PARTNERS

Testosterone Replacement Therapy with Boston Testosterone Partners, now available nationwide. We are New England’s leading choice for Male Wellness and Hormone Restoration for the treatment Low T, hypogonadism, Andropause and ED. Our medical director is a 25 year MD who has, for over ten years, been balancing both male and female hormones. He has been trained as a Hormone Specialist and has balanced well over a thousand male and female patients across the nation. Our patients have constant doctor interaction, he is always available daily to answer questions for our patients.

Our protocols include Sermorelin-GHRP2 Therapy, Glutathione Therapy, numerous Amino Acid Injectable combinations, personally tailored Weight Loss injectables, Cialis or Viagra sublinguals, Oxytocin sprays, and more..

Our services also include proven medical weight loss systems for BOTH men and women utilizing a proprietary combination of B12, B3, MIC, Amino Acids and L-Carnitine specially compounded for our patients. We offer uniquely compounded SuperB and LipoC injectables and capsules, available only from our compounding pharmacy.

And, we offer TESTOSTERONE REPLACEMENT THERAPY FOR MEN with the THE LOWEST PRICES in the nation!