Artificial Sweeteners Linked To Obesity And Diabetes

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People are becoming more health conscious and are bending towards use of artificial sweeteners, especially zero calorie ones. These replacements sugars have been demonstrated to be likely to cause health changes which are associated with obesity and diabetes.

 Worldwide these artificial sweeteners have become one of the most common food additives which are used. They can be found in a wide variety of beverages and food items including diet soda. One of the largest populations was looked at to investigate the effects of these artificial sweeteners and what they are capable of doing within the body, and metabolism of sweeteners and sugar after consumption; and the effects on blood vessel health. Results of this study were presented at the 2018 Experimental Biology Meeting.

 Model rats were fed diets which were high in fructose or glucose or acesulfame potassium, or aspartame; which are natural and zero calorie artificial sweeteners. Differences in concentrations of amino acids, fats, and other blood parameters observed within the animals after 3 weeks of being on the diets, specifically acesulfame potassium was found to be accumulating with in the blood and in higher concentrations damaging the blood vessel wall linings.

There has been a significant rise in diabetes and obesity despite the use of non-caloric artificial sweeteners. Researchers explain that this study shows that both artificial sweeteners and sugar have negative effects on the body which leads to diabetes and obesity, with the mechanisms for the cause of obesity differing for both.

When there was an overload of sugar machinery which handles them breaks down. Non-caloric artificial sweeteners lead to negative changes in metabolism, energy, and fat. More research is required on the subject, but results are enough to show high dietary sugars and artificial sweeteners do have negative health outcomes.

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Your Risk Of Erectile Dysfunction More Than Triples If You Have This Health Condition

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High blood sugar can make it hard to get hard: Men with diabetes are significantly more likely to have erectile dysfunction that those with normal blood sugar readings, new research in the journal Diabetic Medicine concludes. That’s a problem, since diabetes cases have increased four-fold since 1980.

After crunching the numbers from 145 studies including over 88,000 men who averaged 56 years old, the researchers determined that those with diabetes were more than three times as likely to have erectile dysfunction than healthy guys were. In fact, 59 percent of men with diabetes had ED.

What’s more, men with diabetes tended to develop their erectile dysfunction 10 to 15 years earlier than those without the condition did, according to the study. (Want to keep your penis healthy for life?

So how can high blood sugar sink you in the bedroom?

Diabetes can damage your blood vessels and your nerves—both of which are needed for healthy erectile functioning, says Sean Skeldon, M.D., who has previously researched ED and diabetes, but was not involved in this study.

Another important point: Erectile dysfunction is often considered a harbinger of heart disease. That’s because the blood vessel issues that cause ED—say, like plaque buildup—can also affect your heart, too. They just manifest first with problems in the bedroom, since your blood vessels in your penis are smaller than the ones that carry blood to your heart. (Here are 8 other weird facts you never knew about your heart.)

The good news, though, is that many of the risk factors for diabetes are under your control—meaning your penis and your heart could benefit from some prevention strategies. One easy one? Eat three servings of legumes a week. That can cut your risk of diabetes by 35 percent, as we recently reported, possibly because their fiber can help prevent blood sugar spikes.


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Testosterone therapy improves insulin sensitivity in diabetic men

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The January 2016 issue of the journal Diabetes Care reported the outcome of a randomized trial that revealed a beneficial role for testosterone treatment in men with diabetes.

“We hypothesized that testosterone may be an anti-inflammatory and insulin sensitizing agent since it has been known for some time that testosterone reduces adiposity and increases skeletal muscle,” remarked lead researcher Paresh Dandona, MD, PhD, who is a Distinguished Professor at the State University of New York and chief of endocrinology, diabetes and metabolism in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at the University of Buffalo. “Our previous work has shown that obesity is associated with oxidative stress and inflammation, and inflammatory mediators are known to interfere with insulin signaling.”

The trial included 94 type 2 diabetic men, among whom 44 had low testosterone levels and reduced insulin signaling genes indicative of decreased insulin sensitivity. Participants with low testosterone received a weekly testosterone injection or a placebo for 24 weeks. Body weight, body fat, markers of inflammation, insulin sensitivity and other factors were assessed before and after treatment.

At the end of the trial, men who received testosterone experienced a more than six pound average loss of body fat and an equal increase in muscle mass. They also had lower levels of the inflammatory markers C-reactive protein, interleukin-1b and tumor necrosis factor-a. “Most importantly, we saw a dramatic increase in insulin sensitivity, demonstrated by a 32 percent increase in the uptake of glucose by tissues in response to insulin,” Dr Dandona reported.

“Testosterone treatment for men, where indicated, will improve sexual function and increase skeletal muscle strength and bone density,” Dr Dandona noted. “This is the first definitive evidence that testosterone is an insulin sensitizer and hence a metabolic hormone.”

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The type, not just the amount, of sugar consumption matters in risk of health problems

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The type of sugar you eat—and not just calorie count—may determine your risk for chronic disease. A new study is the first of its kind to compare the effects of two types of sugar on metabolic and vascular function. The paper is published ahead of print in the American Journal of Physiology—Heart and Circulatory Physiology.

Female rats were given a liquid solution of either glucose (a form of sugar found naturally in the body after carbohydrates are broken down) or fructose (sugar found in fruit and fruit juices) in addition to their normal diet of solid food. The rats received the sweetened solutions for eight weeks, roughly equivalent to a person eating large amounts of sugar for six years. The sugar-fed rats were compared with a control group that received plain drinking water in addition to their food supply.

Researchers found that although both sugar-fed groups consumed more calories than the control group, the total calorie intake of the glucose-fed rats was higher than the rats that were given fructose. Another surprising observation was that “despite this difference, only the fructose group exhibited a significant increase in final body weight,” wrote the research team.

In addition to higher weight gain, the fructose group showed more markers of vascular disease and liver damage than the glucose group. These included high triglycerides, increased liver weight, decreased fat burning in the liver (a factor that can contribute to fatty liver) and impaired relaxation of the aorta, which can affect blood pressure.

These findings suggest that an increase in the amount of calories consumed due to sweeteners is not the only factor involved in long-term health risks. The type of sugar may also play a role in increasing risk factors for heart disease, diabetes and other chronic diseases.

More information: Gemma Sangüesa et al. TYPE OF SUPPLEMENTED SIMPLE SUGAR, NOT MERELY CALORIE INTAKE, DETERMINES ADVERSE EFFECTS ON METABOLISM AND AORTIC FUNCTION IN FEMALE RATS, American Journal of Physiology – Heart and Circulatory Physiology (2016). DOI: 10.1152/ajpheart.00339.2016

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How Cinnamon Controls Blood Sugar

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We’re not talking about sticky, sugar-laden, insulin-inducing cinnamon rolls here. This much-loved spice has actually shown evidence oflowering blood sugar.

While long used as a flavoring, current research is beginning to confirm health benefits of cinnamon, whose traditional therapeutic use included treatment of chronic bronchitis.1

Cinnamon Controls Diabetes

In a trial of type 2 diabetics reported in 2006, an extract of cinnamon that provided the equivalent of 3 grams powdered cinnamon consumed daily for four months resulted in a 10.3% reduction in fasting plasma glucose from levels measured at the beginning of the study, compared with a 3.4% reduction in the placebo group.2 Participants with higher fasting plasma glucose levels at the beginning of the study derived the greatest benefit.

Cinnamon has also been shown to lower hemoglobin A1c, a marker of long-term glucose control. A randomized trial of 109 type 2 diabetics with elevated hemoglobin A1c levels who received usual care in addition to 1 gram cinnamon daily for 90 days resulted in greater reduction in hemoglobin A1c in comparison with usual care alone.3

Additionally, a trial of 58 poorly controlled type 2 diabetic men and women found reductions in hemoglobin A1c as well as mean systolic and diastolic blood pressures after 12 weeks of cinnamon supplementation compared with a placebo group.4

In Chinese type 2 diabetics, 120 or 360 milligram per day doses of cinnamon extract in addition to gliclazide therapy for three months resulted in a reduction in hemoglobin A1c and fasting blood glucose levels while these levels remained unchanged in the placebo group.5

In a trial that included overweight or obese subjects with impaired fasting blood glucose, cinnamon given twice daily for 12 weeks was associated with an increase in plasma antioxidant status and a decrease in malondialdehyde, a marker of oxidative stress.6

“This study supports the hypothesis that the inclusion of water soluble cinnamon compounds in the diet could reduce risk factors associated with diabetes and cardiovascular disease,” authors A. M. Roussel and colleagues conclude.

Cinnamon Helps Maintain Optimal Blood Sugar Control

A trial of healthy subjects conducted by Swedish researchers found a decrease in blood glucose after eating and a delay in gastric emptying among those who received 6 grams cinnamon compared to those who did not receive it.7

A subsequent study conducted by the Swedish team that evaluated the effects of 1 and 3 grams cinnamon revealed a reduction in serum insulin and an increase in glucagon-like peptide 1 (a hormone that helps prevent high blood glucose levels) in those who received the 3 gram dose.8

Another study involving healthy participants found reductions in total plasma glucose responses to orally administered glucose and improved insulin sensitivity when 5 grams cinnamon was consumed immediately or 12 hours before oral glucose tolerance testing.9

A subsequent study conducted by the researchers in which healthy men were supplemented with 3 grams cinnamon or a placebo for 14 days resulted in reductions in glucose and insulin responses to oral glucose tolerance testing at the end of the treatment period, however, these benefits were rapidly lost once cinnamon was discontinued.10

In nonalcoholic fatty liver disease patients, daily supplementation with 1,500 mg cinnamon for 12 weeks was associated with decreases in fasting blood glucose, insulin resistance, total cholesterol, triglycerides, liver enzymes and high-sensitivity C-reactive protein, a marker of inflammation.11

Polycystic ovary syndrome (PCOS) is a condition not necessarily characterized by cystic ovaries (as its name implies) but by insulin resistance. In a pilot study involving 15 women with PCOS, cinnamon consumed daily for eight weeks resulted in significant improvement in insulin resistance compared to a placebo as indicated by fasting and two hour oral glucose tolerance test results.12

Interestingly, a recent article appearing in Food and Chemical Toxicology suggests that cinnamon inhibits the misfolding of human islet amyloid polypeptide that is regarded as a causative factor in type 2 diabetes mellitus.13The authors of the study identified proanthocyanidins as the main anti-amyloidogenic compounds occurring in cinnamon water extract and discovered that these compounds also decreased human islet amyloid polypeptide aggregation’s damaging and toxic effects.

A review published in 2007 concluded that cinnamon was well tolerated and has a “possible modest effect in lowering plasma glucose levels in subjects with poorly controlled type 2 diabetes”, and adds the usual disclaimer that diabetics should not use cinnamon in place of the proven standard of care.14

A meta-analysis of eight randomized placebo-controlled trials involving participants with diabetes and/or prediabetes published in 2011 concluded that “Cinnamon intake, either as whole cinnamon or as cinnamon extract, results in a statistically significant lowering in fasting blood glucose.”15
Subsequent meta-analyses of six and ten clinical trials involving diabetics came to similar conclusions.16,17

Cinnamon has shown its value among populations who are looking to optimize their glycemic control. There appears to be a variety of valuable, recent human studies on this beloved ancient spice.

We conclude this review with a study of hyperglycemic subjects who were given a 250 mg dried water-extract cinnamon capsule twice per day or a placebo. Participants in this 2010 study showed a reduction in fasting glucose after two months.18 One should take immediate action at the first signs of hyperglycemia to lessen the chances that diabetes will develop.


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  4. Akilen R et al. Diabet Med. 2010 Oct;27(10):1159-67.
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  15. Davis PA et al. J Med Food. 2011 Sep;14(9):884-9.
  16. Akilen R et al. Clin Nutr. 2012 Oct;31(5):609-15.
  17. Allen RW et al. Ann Fam Med. 2013 Sep-Oct;11(5):452-9.
  18. Barbara J Stoecker, et al. The Journal of the Federation of American Societies for Experimental Biology. April 2010, 24 meeting abstract supplement 722.1

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 GAINESVILLE, Fla. – Researchers at the University of Florida have discovered a correlation between grip strength and diabetes and high blood pressure.
The study has been published online ahead of the print version in the American Journal of Preventive Medicine.

Researchers measured the grip strength in normal-weight but high-fat-ratio adults with no history of cardiovascular disease and compared it to the grip strength of normal weight, normal BMI adults and with diagnosed diabetics. The subjects were then tested for A1c levels.

Findings show those who had undiagnosed diabetes measured with a lower grip strength than did individuals who were not diabetic or did not suffer from hypertension.

The results show the weakened grip condition was shown in subjects who had a body mass index within the normal range, but a high proportion of fat to lean muscle. Those percentages for men were more than 25 percent body fat, and for women 35 percent.

This is a subgroup less likely to be screened for hypertension or diabetes because they aren’t considered overweight or obese by BMI measures alone.

The researchers have concluded grip strength is lower in individuals with diagnosed and undiagnosed diabetes and hypertension, and may be an indicator of these diseases in the undiagnosed.

Please contact us for more information on all of our therapies and how testosterone therapy can help with diabetes.

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