Testosterone therapy improves sexual, urinary function in men

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Men with hypogonadism treated long-term with testosterone therapy experience improvements in sexual and urinary function compared with men who are not treated, according to findings published in The Journal of Urology.

Abdulmaged M. Traish, PhD, of the department of biochemistry and department of urology at Boston University School of Medicine, and colleagues evaluated data on men with total testosterone levels of 12.1 nmol/L or less and symptoms of hypogonadism assigned to parenteral testosterone undecanoate 1,000 mg for 12 weeks (n = 360; mean age, 57.4 years) or no testosterone (n = 296; mean age, 64.8 years) for up to 10 years to determine the effect of long-term testosterone therapy on urinary and sexual functions and quality of life. Follow-up was a mean of 6.5 years.

Total testosterone levels were restored to the physiological range (500 ng/dL) in the treated group during the first year and the levels remained stable through follow-up; however, mean testosterone levels remained less than 300 ng/dL in the untreated group.

The untreated group experienced increases in the international prostate symptom score during follow-up compared with decreases in the treated group. At baseline, 50% of the treated group reported mild symptoms and 50% reported moderate symptoms, and 91.5% of the untreated group reported mild symptoms and 8.5% reported moderate symptoms. At the last visit, all the treated group had mild symptoms, and 61% of the untreated group reported mild symptoms and 39% reported moderate symptoms.

Post-voiding bladder volume and score on the Aging Males’ Symptoms scale decreased in the treated group but increased in the untreated group.

Among the treated group, 17.1% had no erectile dysfunction, 30.5% had mild erectile dysfunction, 20.7% mild to moderate, 25.6% moderate and 6.1% severe. At the last visit, the proportion of treated participants without erectile dysfunction increased to 74.4%, 17.1% had mild, 7.3% had mild to moderate and 1.2% had moderate. Among the untreated group, 1.2% had no erectile dysfunction, 31.7% had mild, 52.4% had mild to moderate and 14.6% had moderate. The severity of erectile dysfunction increased in the untreated group through follow-up to 51.2% having moderate and 48.8% having severe.

Prostate volume remained stable in the untreated group but increased from 31.4 mL to 33.2 mL in the treated group.

 

Article Source: https://www.healio.com/endocrinology/hormone-therapy/news/in-the-journals/%7B0c2f828d-0812-42fa-8f66-181eb9a8ee0f%7D/testosterone-therapy-improves-sexual-urinary-function-in-men

 

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National Testosterone Restoration for Men
Wellness & Preventative Medicine

Low Vitamin D Linked to Bladder Cancer

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Systemic review of 7 studies finds increased risk of developing bladder cancer is associated with Vitamin D deficiency.

A systematic review of seven studies was presented on November 8, 2016, at the annual conference of the Society for Endocrinology in Brighton that showed that a Vitamin D deficiency creates an increasing risk of bladder cancer development.

Vitamin D is an essential fat-soluble vitamin produced by the body mainly through exposure to sunlight at a minimum of 5 to 30 minutes a day twice a week. Nine out of 10 Americans fail to meet their daily needs and don’t eat enough foods that naturally contain Vitamin D such as egg yolks, fortified milk, and oily fish. Deficiency is even more pronounced for people living in  the northern parts of the country, especially in the winter.

Supplements of the vitamin are available in vitamin D2 and vitamin D3. One tablet of 1,000 IU Vitamin D3  is equivalent to seven three-ounce cans of tuna, or 25 egg yolks, or eight cups of fortified milk, or 25 cups of fortified cereal. The most common supplement is adding vitamin D to calcium, but it is also added to multivitamins, magnesium, fish oil, and joint support products.

In countries having low sunlight levels, it wouldn’t be feasible to obtain enough Vitamin D from just food. In the United Kingdom, one in five adults are deficient in vitamin D and three in five have low levels. In the winter, 75 percent of the dark-skinned people there have a deficiency.

In the current study, researchers from University Hospital and the University of Warwick reviewed seven studies with 112 to 1125 participants. Five out of seven showed that low levels of vitamin D are linked to an increase in bladder cancer risk. In a separate experiment, researchers looked at cells in the bladder and discovered that they respond to Vitamin D and activate and stimulate an immune response. Dr. Rosemary Bland, the study’s lead author, believes that the immune system has a role in identifying abnormal cells prior to their developing into cancer.

Although further clinical studies are necessary to confirm the above findings, the study adds more information to the evidence regarding how important it is to maintain adequate vitamin D levels.

 

Article Source: http://www.worldhealth.net/news/vitamin-d-linked-bladder-cancer/

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine