Vitamin E Keeps Muscles Healthy

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A study in Free Radical Biology & Medicine provides an explanation of how vitamin E helps maintain muscle.*

Previous research conducted by Paul McNeil and colleagues demonstrated that vitamin E promoted membrane repair in cultured cells and that oxidants inhibited it. For the current study, rats were given normal rodent chow, chow lacking vitamin E, or deficient chow plus supplemental vitamin E, then were tested in their ability to run downhill on a treadmill. Deficient animals demonstrated reduced running ability compared to normal rats and showed increased muscle cell plasma membrane permeability. Examination of their quadriceps muscle fibers revealed diminished size and greater inflammation.

“Every cell in your body has a plasma membrane, and every membrane can be torn,” Dr. McNeil explained. “Part of how we build muscle is a more natural tearing and repair process—that is the no pain, no gain portion—but if that repair doesn’t occur, what you get is muscle cell death.”

Editor’s Note: Dr. McNeil predicts that vitamin E supplementation will be used not only to improve muscle cell membrane repair in diseases such as muscular dystrophy, but as a protective measure for individuals at risk of injury.

Reference
* Free Radic Biol Med. 2015 Jul;84:246-53.

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Low Testosterone, Man Boobs and Dolly Parton….

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By Dr. Elliot Lach
www.bostontestosterone.com

Man Boobs

The article linked below as well as the references that are highlighted provide an easy to understand logic behind, visceral obesity as it relates to low T,high estrogen, prostate problems, wheat and bread consumption.

It’s a vicious cycle, low t results in increased visceral fat- which
increases aromatase- which increases estrogen and lowers testosterone, which contributes to prostate enlargement, which raises risk factors for early death, type 2 diabetes etc, etc.

This is one of the reasons I favor paying attention to estrogen production in obesity and in TRT and prescribing DIMM in men who are potentially going to be getting prostate hypertrophy, ie after age 45 plus or minus. – Dr. Elliot Lach

http://www.wheatbellyblog.com/20…/…/the-dolly-parton-effect/

Read our testimonials here.

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CBlaisdell@CORENewEngland.com
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Boston Testosterone Partners Testimonials and Reviews

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Robert from outside of Boston recently shared his results with the Boston Testosterone Partners/CORE Medical Staff…

Boston Testosterone Partners Testimonials and Reviews

Boston Testosterone Partners Testimonials and Reviews

I am a 70 year old guy who has always been extremely active, bicycling 4000 to 5000 miles / year , hiking, skiing, and working out in the gym.  Over the last few years, I have noticed a gradual drop in my athletic performance, slower recovery from exercise, and a loss of muscle mass.  Even more distressingly, I had begun to have increasingly frequent incidents of erectile dysfunction.  Given that my diet and exercise level was obviously not the issue and that I had no other health issues, these symptoms strongly suggested low testosterone.  I decided to contact Core New England and Charlie Blaisdell.  My initial blood work showed that I had the free testosterone of an 85 to 100 year old man.

Based on the results, and a discussion with ever helpful Charlie, I began testosterone replacement therapy with testosterone cypionate, HCG, and anastrozole.  As a scientist, I reviewed the available literature, which further confirmed the basis for each of these recommended prescriptions, and so I began treatment.  My response was immediate. The following note is excerpted from an email that I sent to Charlie after two weeks on his recommended therapy:

I just wanted to give a quick update on my results so far (after two weeks). Athletically, I feel better than I have in several years. I am finding that when cycling I am in at least one gear higher with the same perceived effort.  Last weekend, my wife and I cycled 45 miles over Brandon Gap and Middlebury Gap in Vermont. Ride was easy with no fatigue!  I am waking up with morning wood, and the sexual issues are gone.  I am getting results from my gym workouts now.

All in all, it is like a miracle!

Update after first ten weeks of therapy:

I continue to feel GREAT!  My wife and I have been biking in Colorado and New Hampshire this summer, and I feel stronger that I have in 20 years!  We did a 77 mile road bike loop through Pinkham Notch, Crawford Notch, routes 115 and 2 through Gorham and back to Pinkham two days ago and the ride was easier for me that it was when I last did it 10 years ago.

After three months:

The results continue to be amazing.  On a recent strenuous hilly week of cycling in Italy, I had no problems keeping up with men 20 years  younger than me, and in all ways I feel at least 20 to 30 years younger that before beginning testosterone replacement therapy.  I have regained the muscle mass that I had lost over the last few years, and I recover from strenuous exertion in the way I did when I was much younger.  Erectile dysfunction is a thing of the past.

Charlie is always available to for advice and to answer questions.  If you suspect low testosterone, my advice is to contact Core New England and Charlie immediately.  It can transform your life!  It did mine!

Low total testosterone levels are associated with an increase in death for men aged 20 through 79 – Boston Testosterone Partners

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Boston Testosterone Partners

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bannerad-bostontestosteronepartners-02-160x600-Ver.02Studies over and over show that low hormones are deleterious to ones health.  When levels are off, one strives to correct the same.  If cholesterol levels are high, you lower.  If thyroid levels are high or low, you correct them.  And, likewise, if hormones levels are off, you balance and optimize them.

This study shows that men aged 20–79 who have low testosterone levels below 8.7 nmol/L (250 ng/dL) have a more than two-fold increased risk of mortality from all causes, compared with those with higher serum testosterone levels. This risk is independent of age, waist circumference, smoking habits, high-risk alcohol use, and physical activity.

Background

The association of low serum testosterone levels with mortality has gained strength in recent research. However, there are few population-based studies on this association.
Objective
This study examined whether low serum testosterone levels are a risk factor for all-cause or cause-specific mortality in a population-based sample of men aged 20–79.

Methods

We used data from 1954 men recruited for the prospective population-based Study of Health in Pomerania, with measured serum testosterone levels at baseline and 195 deaths during an average 7.2-year follow-up.

A total serum testosterone level of less than 8.7 nmol/L (250 ng/dL) was classified as low.

The relationships of low serum testosterone levels with all-cause and cause-specific mortality were analysed by Cox proportional hazards regression models.

Results

Men with low serum testosterone levels had a significantly higher mortality from all causes than men with higher serum testosterone levels (HR 2.24; 95% CI 1.41–3.57).

After adjusting for waist circumference, smoking habits, high-risk alcohol use, physical activity, renal insufficiency, and levels of dehydroepiandrosterone sulfate (DHEAS), low serum testosterone levels continued to be associated with increased mortality (HR 2.32; 95% CI 1.38–3.89).

In cause-specific analyses, low serum testosterone levels predicted increased risk of death from cardiovascular disease (CVD) (HR 2.56; 95% CI 1.15–6.52) and cancer (HR 3.46; 95% CI 1.68–6.68), but not from respiratory diseases or other causes.

Conclusion

Low serum testosterone levels were associated with an increased risk of all-cause mortality independent of numerous risk factors. As serum testosterone levels are inversely related to mortality due to CVD and cancer, it may be used as a predictive marker to improve the ability to predict health risks.

Reference:
Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79.
Haring R, Völzke H, Steveling A, Krebs A, Felix SB, Schöfl C, Dörr M, Nauck M, Wallaschofski H.
Eur Heart J. 2010 Jun;31(12):1494-501

http://www.ncbi.nlm.nih.gov/pubmed/20164245

Boston Testosterone Partners
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781.269.5953

Vitamin D3 improves Mood, Cognition and Pain Tolerance

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Contact Boston Testosterone Partners and CORE Medical about injectable pharmaceutical grade Vitamin D3.

Without the sunshine vitamin, few of us would experience lives free of disease. Two new studies show that increased levels of vitamin D not only reduce the risk of developing cognitive impairments, but also improve widespread chronic pain.


People with higher blood levels of vitamin D live significantly longer than people who have low blood levels of the vitamin.

For the past several years, there has been considerable interest in the role vitamin D plays in improving health and preventing disease. Previous finding show that low levels of vitamin D have been directly associated with various forms of cancer and cardiovascular disease.

A new study, published in Journal of Parkinson’s Disease, examined the relationship between serum vitamin D and neuropsychiatric function in people with Parkinson’s disease (PD) – finding that increased levels of the sunshine vitamin are linked to improved mood and may reduce the risk of developing cognitive impairments.

Led by Dr Amie L. Peterson from the Oregon Health and Sciences University in the US, the team conducted a cross-sectional analysis of 286 patients with PD which indicated that higher serum 25-hydroxyvitamin D levels were associated with lower symptom severity, better cognition, and less depression in the entire group, but the relationships were even stronger in those who were not demented.

“About 30% of persons with PD suffer from cognitive impairment and dementia, and dementia is associated with nursing home placement and shortened life expectancy,” explained Peterson. “We know mild cognitive impairment may predict the future development of dementia.”

“Intervening in the development of dementia has the potential to improve morbidity and mortality in persons with PD.”

Significant negative associations were found between vitamin D levels and disease severity, as measured both by the Hoehn and Yahr Scale and the United Parkinson’s Disease Rating Scale motor section.

A significant negative association was also found for vitamin D levels and depression, as measured by the Geriatric Depression Scale, for both the entire group and those who were not demented, the team added.

These negative associations are suggestive of correlations between decreased Vitamin D levels and both depression and cognitive impairment.

Chronic Pain and Fatigue

According to a press release issued by Elsevier Health Sciences,patients with fibromyalgia syndrome typically have widespread chronic pain and fatigue. For those with low vitamin D levels, vitamin D supplements can reduce pain and may be a cost-effective alternative or adjunct to other treatment, say researchers in the current issue of PAIN.

In addition to pain and fatigue, individuals diagnosed with fibromyalgia (FMS) may experience sleep disorders, morning stiffness, poor concentration, and occasionally mild-to-severe mental symptoms such as anxiety or depression.

Calcifediol (also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (OH)D) is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3). Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. The concentration of calcifediol in blood is considered the best indicator of vitamin D status.

Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms. “Low blood levels of calcifediol are especially common in patients with severe pain and fibromyalgia. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients,” says lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital, Speising, Vienna, Austria. “We therefore set out to determine whether raising the calcifediol levels in these patients would alleviate pain and cause a general improvement in concomitant disorders.”

In a randomized controlled trial, 30 women with FMS with low serum calcifediol levels (below 32ng/ml) were randomized to a treatment or control group. The goal for the treatment group was to achieve serum calcifediol levels between 32 and 48ng/ml for 20 weeks via oral cholecalciferol supplements. Serum calcifediol levels were reevaluated after five and 13 weeks, and the dose was reviewed based on the results. The calcifediol levels were measured again 25 weeks after the start of the supplementation, at which time treatment was discontinued, and after a further 24 weeks without supplementation.

Twenty-four weeks after supplementation was stopped, a marked reduction in the level of perceived pain occurred in the treatment group. Between the first and the 25th week on supplementation, the treatment group improved significantly on a scale of physical role functioning, while the placebo group remained unchanged. The treatment group also scored significantly better on a Fibromalgia Impact Questionnaire (FIQ) on the question of “morning fatigue.” However, there were no significant alterations in depression or anxiety symptoms.

“We believe that the data presented in the present study are promising. FMS is a very extensive symptom complex that cannot be explained by a vitamin D deficiency alone. However, vitamin D supplementation may be regarded as a relatively safe and economical treatment for FMS patients and an extremely cost-effective alternative or adjunct to expensive pharmacological treatment as well as physical, behavioral, and multimodal therapies,” says Wepner. “Vitamin D levels should be monitored regularly in FMS patients, especially in the winter season, and raised appropriately.”

Sources:
metapress.com
elsevierhealth.com

Mae Chan holds degrees in both physiology and nutritional sciences. She is also blogger and and technology enthusiast with a passion for disseminating information about health.

What is Testosterone and why is it so important?

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Boston Testosterone Partners, Boston, Massachusetts

Testosterone is a hormone produced primarily in the male testes.  It is the lifeblood of every man.  Testosterone helps maintain men’s bone density, fat distribution, muscle strength and mass, red blood cell production, sex drive and sperm production.  It’s what makes men, men frankly.

The normal range for testosterone is wide, and men’s testosterone levels usually change throughout their lives.

Naturally, testosterone peaks during adolescence and early adulthood.  But as men get older, testosterone levels gradually fall – typically about 1 percent a year after age 30.   It is important to find out if low testosterone is a result of normal aging, or if it could be due to a medical problem.

Declines in testosterone levels can cause symptoms.  Fatigue and low sexual interest are the most common while some men also see changes in beard and body hair growth.  Muscle wasting and a decrease in muscle strength can be a result of low testosterone also.  ED can occur with testosterone deficiency.  Fat gains may also be a cause of your low testosterone levels.

Disorders that may lead to low testosterone include hypogonadism, rare conditions of the testicles or the pituitary gland in which the body does not produce sufficient or adequate amounts of testosterone.  Other conditions that can affect testosterone levels are environmental related, excessive weight gains, thyroid problems, obstructive sleep apnea, depression and excessive alcohol use.

Follow-up blood tests and examinations will show if a medical condition is contributing to low testosterone.  Blood testing will also show your free testosterone levels, or the amount that is bioavailable to us.  Proper blood testing will always include estradiol, a sister hormone of testosterone.  If an underlying medical condition is identified, treatment for that disorder may be all you need to bring your testosterone level back into the normal range.

Testosterone replacement therapy may be recommended to correct your testosterone deficiency.

If you feel that you may be suffering for any signs or symptoms of low testosterone, Contact Boston Testosterone Partners today for more information on how you can get tested.

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Not feeling your old-self? Low Energy? Weight gain? Libido loss?

Been shrugged off by your primary care physician when you asked about your testosterone level?

Contact Boston Testosterone, the nation’s leading Men’s Health Clinic to get your hormones tested.

Don’t Delay – Get Tested!

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Flaws and Misinformation spread about Testosterone Therapy, Part II

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bannerad-bostontestosteronepartners-02-160x600-Ver.02http://www.BostonTestosterone.com

Boston, Massachusetts – The Journal of American Medical Association relayed that testosterone treatment may increase the risk of cardiovascular ailments. The basis of the study cautioned that men with pre-existing cardiovascular ailments might need to avoid testosterone. The holes in this study are so large it is beyond comprehension that any journalist or reporter could take the study seriously.

It’s been long understood that untreated prolonged low testosterone can increase the risk of cardiovascular incidence. Although prescribed testosterone, the men in this study remained at a low level state. Nearly half were never retested during treatment. Recent data shows that men with total testosterone below 550 ng/dl increase their risk of cardiovascular incidence, while men 550 ng/dl and above reduce their risk by 30%.

http://content.onlinejacc.org/article.aspx?articleid=1146860 

Most participants in this study held their testosterone levels at 332 ng/dl!  They actually had deficient testosterone!

Since recommended guidelines of treatment were not followed, there were no reports showing measurements of estradiol or hematocrit. High levels of estradiol or hematocrit can increase cardiovascular risk. However, both estradiol and hematocrit are easily managed when proper treatment guidelines are followed.

The study also showed the majority of participants used testosterone patches. Once a popular method of testosterone delivery, testosterone patches are no longer used when proper treatment guidelines are followed. Patches are highly inefficient in terms of optimizing testosterone, resulting in continued hypogonadal symptoms and increased cardiovascular risk.

Perhaps the most startling piece of the study that was missed altogether or largely ignored by most reports was the rate of reported cardiovascular events. Of those taking testosterone, 10% experienced a cardiovascular event. Of those not taking testosterone, 21% experienced a cardiovascular event. The rate of mortality was greater in those who did not take testosterone.

Studies of this nature are difficult to take seriously when their parameters do not meet standard treatment guidelines. Such studies might parallel this absurd example: Shooting a man who was given testosterone, then blaming the testosterone rather than the gaping bullet hole for his demise.  Courtesy of lowtestosterone.com.

Read also:  https://bostontestosterone.wordpress.com/2014/03/18/flaws-and-disinformation-continue-to-distort-the-truth-about-testosterone-replacement-therapy-for-men/

You too can change the vicious pattern of aging and disease by engaging the team of rejuvenation experts at BTP/CORE today.

Learn about our proprietary Preventative Medicines, stop age-related disease and get into the Greatest Health of your Life with www.BostonTestosterone.com

For for more information on getting started please contact Clinic Director Charlie Blaisdell at CBlaisdell@CoreNewEngland.com

BTP/CORE New England
920 Washington Street
Norwood, MA 02062
www.BostonTestosterone.com
CBlaisdell@CORENewEngland.com
Clinic: 781-269-5953
Direct: 617-869-7961
Fax: 617-336-3400

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