Opioid Use Linked to Low Testosterone

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Exposure to opioids is associated with increased likelihood of low testosterone levels, with increased odds as age and number of comorbidities increase, according to a study published in Pain Medicine.

Maria Soledad Cepeda, MD, PhD, from Janssen Research & Development in Titusville, NJ, and colleagues used data from the 2011 to 2012 National Health and Nutrition Examination Survey to examine whether opioid use contributes to changes in testosterone levels. Testosterone levels were compared for participants who responded that they had been exposed to prescription opioids in the past 30 days (320 participants) versus those who were unexposed (4,909 participants).

The researchers found that the odds of having low testosterone levels were higher for participants on opioids versus unexposed participants (odds ratio, 1.40). The odds of having low testosterone levels increased significantly in all categories as the age and number of comorbidities increased, after adjustment for opioid exposure. The odds of having low testosterone levels were increased for participants aged older than 70 years versus those aged 17 to 45 years (odds ratio, 1.70) and for participants with more than two versus no comorbidities (odds ratio, 1.69).

“When assessing the impact of opioids on testosterone, the effects of age and medical conditions should be considered,” the authors write.

All authors disclosed employment by pharmaceutical companies, including Janssen Research & Development, which funded the study.

Source http://www.renalandurologynews.com/hypogonadism/opioid-use-linked-to-low-testosterone/article/462834/

  1. Soledad Cepeda M, Zhu V, Vorsanger G, and Eichenbaum G. Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. Pain Medicine. doi:10.1111/pme.12843.

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Testosterone Therapy is associated with reduction in pain in men

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Testosterone Replacement Therapy Doctors

New studies have associated a reduction in pain in men undergoing testosterone replacement therapy.  The results were presented at The Endocrine Society’s 95th Annual Meeting in San Francisco.

“In this study, we attempted to determine whether testosterone replacement improves pain perception and tolerance, and quality of life in men with low testosterone levels due to narcotic analgesics,” said the study’s lead author Shehzad Basaria, MD, Medical Director, Section of Men’s Health, Aging, & Metabolism at Brigham & Women’s Hospital, Harvard Medical School, in Boston, MA. “We found that testosterone administration in these men was associated with a greater reduction in several measures of pain sensitivity during laboratory pain testing compared with men who were on placebo.”

In addition to being highly addictive, opioid use is associated with a number of side effects, including suppression of the hypothalamic-pituitary-gonadal axis in both women and men, resulting in decreased testosterone production. Low testosterone, in turn, can result in sexual dysfunction, decreased muscle mass, increased fat mass and decreased quality of life.

Previous animal research has demonstrated that castration of rodents is associated with increased pain perception while testosterone replacement reduces pain perception, suggesting an analgesic effect of this sex steroid. Whether these beneficial effects can be replicated in humans, however, remained unclear.

In this study, investigators found that, compared to placebo, testosterone therapy significantly improved pain perception and tolerance during laboratory pain testing. Testosterone therapy also improved some aspects of quality of life.

“If larger studies confirm these findings, testosterone therapy in this patient population may be beneficial in improving pain perception,” Basaria said.

The study included 84 men ages 18-64 years old with opioid-induced testosterone deficiency. Their average age was 49 years. Of this group, 65 participants completed the study. Investigators randomly assigned participants to receive either testosterone gel, applied to the skin, or placebo, for 14 weeks. Thirty-six men received the testosterone gel, and 29 received a placebo.

At the beginning of the study, and then again at 14 weeks, the investigators assessed pain measures and quality-of-life parameters.

For more information on our unique Men’s Testosterone and Wellness therapies visit us athttp://www.BostonTestosterone.com or http://www.Facebook.com/BostonTestosterone.

“The Greatest Health of Your Life”℠
Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine
http://www.BostonTestosterone.com
http://www.facebook.com/BostonTestosterone
855-617-MEDS (6337)

Testosterone therapy may help improve pain in men with low testosterone

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Testosterone therapy is associated with decreased pain perception in men with low testosterone levels related to opioid (narcotic) pain relievers (analgesics), a new study finds. The results were presented Monday at The Endocrine Society’s 95th Annual Meeting in San Francisco.

 “In this study, we attempted to determine whether testosterone replacement improves pain perception and tolerance, and quality of life in men with low testosterone levels due to narcotic analgesics,” said the study’s lead author Shehzad Basaria, MD, Medical Director, Section of Men’s Health, Aging, & Metabolism at Brigham & Women’s Hospital, Harvard Medical School, in Boston, MA. “We found that testosterone administration in these men was associated with a greater reduction in several measures of pain sensitivity during laboratory pain testing compared with men who were on placebo.”

Opioids belong to a class of pain-reducing drugs that are used to relieve chronic pain from injuries, surgery and cancer treatment. These drugs include morphine, codeine, fentanyl and oxycodone, and are among the most frequently prescribed medications in the United States today.

In addition to being highly addictive, opioid use is associated with a number of side effects, including suppression of the hypothalamic-pituitary-gonadal axis in both women and men, resulting in decreased testosterone production. Low testosterone, in turn, can result in sexual dysfunction, decreased muscle mass, increased fat mass and decreased quality of life.

Previous animal research has demonstrated that castration of rodents is associated with increased pain perception while testosterone replacement reduces pain perception, suggesting an analgesic effect of this sex steroid. Whether these beneficial effects can be replicated in humans, however, remained unclear.

In this study, investigators found that, compared to placebo, testosterone therapy significantly improved pain perception and tolerance during laboratory pain testing. Testosterone therapy also improved some aspects of quality of life.

“If larger studies confirm these findings, testosterone therapy in this patient population may be beneficial in improving pain perception,” Basaria said.

The study included 84 men ages 18-64 years old with opioid-induced testosterone deficiency. Their average age was 49 years. Of this group, 65 participants completed the study. Investigators randomly assigned participants to receive either testosterone gel, applied to the skin, or placebo, for 14 weeks. Thirty-six men received the testosterone gel, and 29 received a placebo.

At the beginning of the study, and then again at 14 weeks, the investigators assessed pain measures and quality-of-life parameters.

Solvay (now Abbott) Pharmaceuticals, Inc. funded the study.

Source: http://medicalxpress.com/news/2013-06-testosterone-therapy-pain-men.html

For for more information on our therapies please contact Clinic Director Charlie Blaisdell at CBlaisdell@CoreNewEngland.com

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Testosterone Therapy is associated with reduction in pain in men

Leave a comment

BOSTON TESTOSTERONE PARTNERS – TESTOSTERONE REPLACEMENT THERAPY DOCTORS

Testosterone Replacement Therapy Doctors

Boston Testosterone Partners

Boston, Massachusetts—- New studies have associated a reduction in pain in men undergoing testosterone replacement therapy.  The results were presented at The Endocrine Society’s 95th Annual Meeting in San Francisco.

“In this study, we attempted to determine whether testosterone replacement improves pain perception and tolerance, and quality of life in men with low testosterone levels due to narcotic analgesics,” said the study’s lead author Shehzad Basaria, MD, Medical Director, Section of Men’s Health, Aging, & Metabolism at Brigham & Women’s Hospital, Harvard Medical School, in Boston, MA. “We found that testosterone administration in these men was associated with a greater reduction in several measures of pain sensitivity during laboratory pain testing compared with men who were on placebo.”

In addition to being highly addictive, opioid use is associated with a number of side effects, including suppression of the hypothalamic-pituitary-gonadal axis in both women and men, resulting in decreased testosterone production. Low testosterone, in turn, can result in sexual dysfunction, decreased muscle mass, increased fat mass and decreased quality of life.

Previous animal research has demonstrated that castration of rodents is associated with increased pain perception while testosterone replacement reduces pain perception, suggesting an analgesic effect of this sex steroid. Whether these beneficial effects can be replicated in humans, however, remained unclear.

In this study, investigators found that, compared to placebo, testosterone therapy significantly improved pain perception and tolerance during laboratory pain testing. Testosterone therapy also improved some aspects of quality of life.

“If larger studies confirm these findings, testosterone therapy in this patient population may be beneficial in improving pain perception,” Basaria said.

The study included 84 men ages 18-64 years old with opioid-induced testosterone deficiency. Their average age was 49 years. Of this group, 65 participants completed the study. Investigators randomly assigned participants to receive either testosterone gel, applied to the skin, or placebo, for 14 weeks. Thirty-six men received the testosterone gel, and 29 received a placebo.

At the beginning of the study, and then again at 14 weeks, the investigators assessed pain measures and quality-of-life parameters.

For more information on our unique Men’s Testosterone and Wellness therapies visit us at http://www.BostonTestosterone.com or http://www.Facebook.com/BostonTestosterone.

“The Greatest Health of Your Life”℠
Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine
http://www.BostonTestosterone.com
http://www.facebook.com/BostonTestosterone
855-617-MEDS (6337)