Is testosterone replacement therapy the right thing for aging males?

Leave a comment

A study suggests that exercise can reduce the risk of heart damage for middle-aged adults and seniors. According to the study, even those who are obese will benefit from physical activity. Wochit

Testosterone (T) is a naturally occurring hormone in men, and most of it is produced in the testicles.

At puberty, T production escalates, bringing about masculinizing changes in muscle mass.  also promotes sex drive, sperm and red blood cell production, bone mass and determines how men store body fat.

It can impact quality of life issues as well, like mood, energy and motivation.

Beginning at about age 30, T production begins to decline on average by about 1 percent per year, plummeting late in life. This causes all sorts of problems, including lack of sex drive, inability to sleep, loss of muscle and bone mass, increased belly fat, the list goes on. Reversing these symptoms and improving the quality of life is the reason T replacement therapy (TRT) clinics supervised by physicians have sprung up around the country.

Although it is considered a male hormone, women also produce a modest amount of T in the ovaries. After menopause, estrogen production declines, which alters the ratio of estrogen to T, explaining why women begin taking on some male characteristics, like storing more fat around the midsection, rather than on the hips, thighs and buttocks as occurs earlier in life.

TESTOSTERONE REPLACEMENT THERAPY

Is TRT a good thing? It can be when managed responsibly. If you are older, and your T level is very low and falls below the normal range, it makes sense to address it with TRT because it can negatively impact health, increasing risks associated with diabetes, obesity and osteoporosis. Low T also may shorten life, but this is controversial because when TRT raises T levels it has not been shown to extend life.

More is not always better, and many TRT clinics are viewed with suspicion because they advertise that it’s possible to feel like you are 25 years old again, even though you are decades older. Perhaps this is possible, but at what price, and if you are taking huge doses of T, could you be damaging your health?

Research studies in 2013 and 2014 indicated that TRT increased the risk of heart disease in men 65 and older, and in younger men with a history of heart disease. However, subsequent studies refute these findings and some show a deceased risk of heart disease. Another area of concern is an increased risk of prostate cancer, but this, too, is controversial. There does appear to be solid evidence that TRT can increase the risk of blood clots and stroke, plus sleep apnea, acne and breast enlargement.

All in all, some experts believe the benefits outweigh the risks, while others are more cautious because TRT hasn’t been around long enough or impacted enough men to draw meaningful conclusions. Time will tell. In the meantime, like most things in life, moderation is the best approach.

THE BOTTOM LINE

TRT has a place and can be beneficial if managed prudently. Just be careful of extreme approaches and promises that seem too good to be true. As for AS, there is no justifiable reason for athletes to be taking them. Ever!

Written by: Bryant Stamford

Article Source: http://www.courier-journal.com/story/life/wellness/health/2017/09/07/testosterone-replacement-therapy-aging-males/569708001

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Advertisements

13 Foods You’re Better Off Avoiding Before Having Sex

Leave a comment

While most of us are aware of the foods that act as aphrodisiacs, only a handful are aware of the foods we should avoid at all costs. Not only will these make you feel bloated, unsexy and lethargic, they are likely to prevent you from getting it on!

#1. French fries

As tempting as reaching for those French fries are at all times fried foods (including the likes of pizza) are disastrous for your libido. They lower your testosterone levels, decrease blood circulation, and reduce your chances of maintaining strong erections.

#2. Hot dogs

Thinking of chomping on a hot dog towards the end of your grand night out before heading back for a raunchy session under the sheets? Although this super popular snack is great when paired with beer while watching your favorite sport it’s loaded with the kind of saturated fat that can clog the arteries that improve blood flow to your sexual organs. 

#3. Processed foods

Whether it is the aforementioned hot dog or the savory cupcake, the trans fat and sugars in processed food items can weigh down your digestion and slow your blood flow; hampering your sex drive.  Over time this can cause a loss of muscle mass, increase in fat and a dip in your testosterone levels.

#4. Canned or packaged foods

Canned or packaged foods are loaded with crippling levels of sodium. When we say crippling we mean that it can elevate your blood pressure to unfavorable levels and blockade the flow of blood to certain parts your body, like your genitals, leaving your limp.  

#5. Beer

If your night out entails having sex, later on, make sure it doesn’t include cracking open pints of beer in the build-up to it. Although it might give you the buzz you seek the phytoestrogens present in beer stand a good chance to alter the hormones that tamper with your libido. 

#6. Energy drinks

These bottled up potions of liquid give you instant energy due to the caffeine and sugar they are loaded with, but they do just the opposite to your sexual stamina. Once the caffeine and sugar burn off in your system they leave you with lesser energy than you had before. Studies also suggest that it lowers the level of the hormone serotonin that impacts your mood.

#7. Tonic water

 

Although this makes for a perfect combination with gin it doesn’t fair that well with your testosterone levels. The chemical quinine present in the water not only kills your sex drive and lowers your sperm count but it also can cause gas and bloating. 

#8. All sorts of beans

 

Love your rice and beans? Science has it that beans contain oligosaccharides (sugar molecules that the body cannot fully breakdown), which create gas and excessive cramping. And these are the last two things you want to be feeling down there when you’re setting yourself to get it on.

#9. Cruciferous vegetables

 

Sometimes the healthiest of vegetables can be just what you need to avoid in certain situations. Cruciferous vegetables like cabbage, broccoli and cauliflower create a lot of gas since our body cannot digest the natural sugars found in them. The methane, carbon dioxide and hydrogen produced by your body, as a result, can really stink up your surroundings.

#10. Tofu

Tofu has earned its name as one of the healthier options of protein for vegetarians and non-vegetarians as well, but not so much before a sexual encounter. Soy laden products increase your estrogen levels that have shown to decrease the estrogen levels in both sexes.

#11. Onions and garlic

If your food is loaded with onions and garlic, like most of our food is, try to avoid them in your meal prep before you engage in coitus. These pungent vegetables can affect your body odor for the worse; similar to how spices do. 

#12. Red meats

 

If you’re big on eating meats like lamb, pork or beef, especially on night outs where you’re looking forward to a romp in the sack, later on, swap it with seafood instead. Red meat is associated with the production of foul-smelling gas that can be downright offensive in nature!

#13. Cream-based sauces

Avoid cream-based sauces, such as the ones they use to make pasta in some restaurants; their heavy nature will put your system into a slump. The cream can upset your stomach and cause gas if you’re lactose intolerant dampening your elevated spirits.

 

Written By: REGI GEORGE JENARIUS

Article Source: http://www.indiatimes.com/health/healthyliving/13-foods-you-re-better-off-avoiding-before-having-sex-329846.html

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Testosterone therapy improves sexual, urinary function in men

Leave a comment

Men with hypogonadism treated long-term with testosterone therapy experience improvements in sexual and urinary function compared with men who are not treated, according to findings published in The Journal of Urology.

Abdulmaged M. Traish, PhD, of the department of biochemistry and department of urology at Boston University School of Medicine, and colleagues evaluated data on men with total testosterone levels of 12.1 nmol/L or less and symptoms of hypogonadism assigned to parenteral testosterone undecanoate 1,000 mg for 12 weeks (n = 360; mean age, 57.4 years) or no testosterone (n = 296; mean age, 64.8 years) for up to 10 years to determine the effect of long-term testosterone therapy on urinary and sexual functions and quality of life. Follow-up was a mean of 6.5 years.

Total testosterone levels were restored to the physiological range (500 ng/dL) in the treated group during the first year and the levels remained stable through follow-up; however, mean testosterone levels remained less than 300 ng/dL in the untreated group.

The untreated group experienced increases in the international prostate symptom score during follow-up compared with decreases in the treated group. At baseline, 50% of the treated group reported mild symptoms and 50% reported moderate symptoms, and 91.5% of the untreated group reported mild symptoms and 8.5% reported moderate symptoms. At the last visit, all the treated group had mild symptoms, and 61% of the untreated group reported mild symptoms and 39% reported moderate symptoms.

Post-voiding bladder volume and score on the Aging Males’ Symptoms scale decreased in the treated group but increased in the untreated group.

Among the treated group, 17.1% had no erectile dysfunction, 30.5% had mild erectile dysfunction, 20.7% mild to moderate, 25.6% moderate and 6.1% severe. At the last visit, the proportion of treated participants without erectile dysfunction increased to 74.4%, 17.1% had mild, 7.3% had mild to moderate and 1.2% had moderate. Among the untreated group, 1.2% had no erectile dysfunction, 31.7% had mild, 52.4% had mild to moderate and 14.6% had moderate. The severity of erectile dysfunction increased in the untreated group through follow-up to 51.2% having moderate and 48.8% having severe.

Prostate volume remained stable in the untreated group but increased from 31.4 mL to 33.2 mL in the treated group.

 

Article Source: https://www.healio.com/endocrinology/hormone-therapy/news/in-the-journals/%7B0c2f828d-0812-42fa-8f66-181eb9a8ee0f%7D/testosterone-therapy-improves-sexual-urinary-function-in-men

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Hair loss warning: THIS popular medication could trigger erectile dysfunction

Leave a comment

HAIR loss – or alopecia – affects half of men over the age of 30 in the UK, but using certain medications to counteract it could cause erectile dysfunction – which is the inability of a man to get and maintain an erection.

By the time they reach their fifties, over 50 per cent of men will experience some degree of baldness, according to the NHS.

The most common type of hair loss is male-pattern baldness, where sufferers often experience a receding hairline followed by thinning of hair on the crown and temples.

However, there are now a number of treatment options, and the Alopecia Treatment Market Size is set to see sustained growth between now and 2022.

These include hair transplants and medications, but experts are warning of the risks involved.

Doctors at the International Andrology London have warned that men undergoing a hair transplant could suffer erectile dysfunction as a result.

They are raising awareness of a condition called post-Finasteride Syndrome which is caused by a drug called 5-alpha reductase type II enzyme inhibitor or Finasteride.

The medication works by halting hair loss in men with thinning hair.

It also assists hair transplant treatment by stopping the body from rejecting new hair.

However, it can cause some worrying side-effects.

These include neurological and physical symptoms such as muscle atrophy, chronic fatigue and depression.

Such is their prevalence that the Post-Finasteride Syndrome Foundation has been created to boost awareness.

Dr Amr Raheem at International Andrology said: “Erectile dysfunction, loss of libido, reduction of semen creation and curvature of the penis (known as Peyronie’s) are all part of this disturbing reaction.

“Hair transplant clinics are aware of the issue and have an obligation to explain the risks to patients while the drug itself is becoming more clearly labelled.

“However, understand that investment into finding alternatives to this drug, which can provide results without compromising patients’ health, are ongoing.

“At International Andrology London, we encourage men who are developing a serious hair condition such as alopecia and know that they will need hair replacement to make a pre-emptive move, seeking out treatment for erectile dysfunction, such as shockwave therapy, before they experience the problem.

“This builds up muscle resistance and manages the condition through the hair treatment.

“An alternative option is to take Minoxidil spray which improves the circulation to the scalp and has been proven to help without the same side effects.”

Written By LAUREN CLARK

Article Source: http://www.express.co.uk/life-style/health/841366/hair-loss-erectile-dysfunction-transplant-treatment-medication-finasteride-alopecia-bald

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

The Benefits of High Cholesterol

Leave a comment

People with high cholesterol live the longest.

This statement seems so incredible that it takes a long time to clear one´s brainwashed mind to fully understand its importance.

Yet the fact that people with high cholesterol live the longest emerges clearly from many scientific papers.

Consider the finding of Dr. Harlan Krumholz of the Department of Cardiovascular Medicine at Yale University, who reported in 1994 that old people with low cholesterol died twice as often from a heart attack as did old people with a high cholesterol.

Supporters of the cholesterol campaign consistently ignore his observation, or consider it as a rare exception, produced by chance among a huge number of studies finding the opposite.

But it is not an exception; there are now a large number of findings that contradict the lipid hypothesis.

To be more specific, most studies of old people have shown that high cholesterol is not a risk factor for coronary heart disease.

This was the result of my search in the Medline database for studies addressing that question.

Eleven studies of old people came up with that result, and a further seven studies found that high cholesterol did not predict all-cause mortality either.

Now consider that more than 90 % of all cardiovascular disease is seen in people above age 60 and that almost all studies have found that high cholesterol is not a risk factor for women.

This means that high cholesterol is only a risk factor for less than 5 % of those who die from a heart attack.

But there is more comfort for those who have high cholesterol; six of the studies found that total mortality was inversely associated with either total or LDL-cholesterol, or both.

This means that it is actually much better to have high than to have low cholesterol if you want to live to be very old.

High Cholesterol Protects Against Infection

Many studies have found that low cholesterol is in certain respects worse than high cholesterol.

For instance, in 19 large studies of more than 68,000 deaths, reviewed by Professor David R. Jacobs and his co-workers from the Division of Epidemiology at the University of Minnesota, low cholesterol predicted an increased risk of dying from gastrointestinal and respiratory diseases.

Most gastrointestinal and respiratory diseases have an infectious origin.

Therefore, a relevant question is whether it is the infection that lowers cholesterol or the low cholesterol that predisposes to infection?

To answer this question Professor Jacobs and his group, together with Dr. Carlos Iribarren, followed more than 100,000 healthy individuals in the San Francisco area for fifteen years.

At the end of the study those who had low cholesterol at the start of the study had more often been admitted to the hospital because of an infectious disease.

This finding cannot be explained away with the argument that the infection had caused cholesterol to go down, because how could low cholesterol, recorded when these people were without any evidence of infection, be caused by a disease they had not yet encountered?

Isn´t it more likely that low cholesterol in some way made them more vulnerable to infection, or that high cholesterol protected those who did not become infected? Much evidence exists to support that interpretation.

Written By: Uffe Ravnskov, MD, PhD

Article Source: https://www.functionalmedicineuniversity.com/public/924.cfm

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Ben Stiller Wants Men to Test for Prostate Cancer

Leave a comment

Actor Ben Stiller was as surprised as anyone when he heard these words: “So yeah, it’s cancer.”

After all, he was only 48 and had no real reason to suspect that he had cancer, especially prostate cancer, which many people think of as an older man’s disease.

“I have no history of prostate cancer in my family and I’m not in the high-risk group,” he wrote in a public posting detailing his experience. “I had no symptoms.”

So how did the star of movies including There’s Something About MaryMeet the Parents, and Zoolander end up getting diagnosed in the first place? And what does his case have to say about the way we diagnose and treat prostate cancer in the United States?

Stiller’s story began two years before the day in June 2014 when he was diagnosed with prostate cancer. This is when his doctor, a “thoughtful internist”, gave him a simple and inexpensive PSA screening test. This was the first of many PSA tests over the next few years.

A one-time modest elevation of PSA blood levels can be explained by several factors that are often correctable. So the best course of action is to have follow-up PSA tests to monitor what direction the PSA is moving in.

As follow-up PSA tests were performed, Ben Stiller’s doctor noted a gradual rise in Stiller’s PSA over his earlier baseline. These rising levels triggered a referral to a urologist, who did further testing, including a digital rectal exam, an MRI, and finally a biopsy that confirmed the diagnosis.

Three months after his diagnosis, Stiller had undergone treatment—in his case a robotic-assisted laparoscopic radical prostatectomy, or removal of his prostate gland during a minimally invasive surgery—and was cancer free. That could have been the end of it, but after doing his research into prostate cancer screening and diagnosis, Stiller realized he couldn’t be silent about his experience. He’s been spreading the same message ever since: “Taking the PSA test saved my life.”

This might not seem like a controversial statement—after all, it might seem hard to argue against a simple blood test that can identify prostate cancer early enough to treat it before it spreads and without major side effects. But in fact, due to recent chaos in the official recommendations for PSA blood testing, tens of thousands of American men are skipping the very test that possibly saved Stiller’s life on the advice of their doctors and with potentially devastating consequences.

History of Screening Recommendations

The PSA test is used to measure prostate-specific antigen, a protein that is produced by the prostate gland.

PSA levels rise in aging men and can be the first signal of underlying prostate cancer. So the PSA blood test is used to identify men who may have prostate malignancy and need further evaluation.

This simple blood test was approved by the FDA in 1994, allowing men to begin monitoring their PSA levels and identify possible tumors long before they become dangerous.1

Since PSA testing was introduced, the risk of dying from prostate cancer among men who were regularly screened declined by as much as 42%.2,3

Despite this drop, widespread PSA screening remained controversial in the medical community.

Prostate cancer is typically a slow-growing cancer, and the current biopsy and treatment methods, including the kind of less-invasive surgical removal that Stiller underwent, carry risks such as pain, incontinence and impotence. Some doctors worried that the PSA test, which can detect very slight increases in PSA levels, might be causing men with low-risk cancers to undergo biopsies and possibly unnecessary treatment.

Based on these concerns, in 2012, the US Preventive Service Task Force (USPSTF) issued a stunning update to prostate screening recommendations. Drawing its conclusions from the results of a $400 million federal study, the USPSTF advised against PSA screening for healthy men, saying that PSA screening has “no net benefit.”4-6 The American Cancer Society soon revised its recommendations, steering healthy, average-risk men away from PSA screening until age 50, with revised recommendations for men with a family history of prostate cancer.7

These guidelines caused immediate uproar in the medical community, including rebuttals from Life Extension® urging men over age 40 to continue having annual PSA blood tests. By 2016, the USPSTF announced it was reconsidering its prior recommendations against PSA screening.

In 2017, a new draft recommendation was released for public input. This time, the USPSTF slightly backtracked, saying that the risks and benefits of PSA screening are “closely balanced” in men between the ages of 55 and 69 and they should seek their doctor’s advice on PSA screening. Men aged 54 and under and those over the age of 70 would still be counseled to avoid PSA screening. These new, slightly softer guidelines were still not finalized as of May 2017, and the agency was soliciting public input.8

In Stiller’s case, following even the updated guidelines might have meant disaster—he was still too young to be screened according to the USPSTF (United States Preventive Service Task Force).

“If he [Ben Stiller’s doctor] had waited, as the American Cancer Society recommends, until I was 50, I would not have known I had a growing tumor until two years after I got treated,” he wrote. “If he [Ben Stiller’s doctor] had followed the US Preventive Service Task Force guidelines, I would never have gotten tested at all, and not have known I had cancer until it was way too late to treat successfully.”

The USPSTF’s original recommendations against screening were partly based on the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. This huge trial assigned 76,685 men aged 55 – 74 years to one of two study arms. The first group (38,340 men) underwent annual PSA testing for 6 years and an annual digital rectal exam for 4 years. The control group (38,345 men) underwent normal care, with occasional “opportunistic screening” but no regular PSA monitoring. At the end of the 13-year follow-up period, researchers announced there was “no evidence of a mortality benefit” for annual PSA screening.9 The USPSTF recommendation against PSA screening soon followed.

Life Extension, which has long supported PSA screening, issued a detailed rebuttal challenging the findings of this study. In fact, the study was deeply flawed thanks to widespread “contamination” of the control arm.

While Life Extension was early in identifying the obvious flaws with this study, it wasn’t long until astute research groups began to catch up. In early 2016, a group of urologists from the New York Presbyterian Hospital and Weill Cornell Medical College in New York published a letter in the New England Journal of Medicine confirming what Life Extension suspected.10

The shocking truth was that more than 80% of the men in the control group—which was supposed to only receive “occasional” PSA screening—reported at least one PSA test during the trial. In fact, by some measures, the men in the control group received more PSA screening than men in the PSA screeningarm!10

Their conclusion? “We’re going to have to reconsider this issue.”11

Further support for this position was published in another large study, this one called the European Randomized Study of Screening for Prostate Cancer. This study randomized 182,000 men aged 50 to 74 to a “usual care” control group or a group with PSA screening every two to seven years. Spread across seven research centers in Europe, the group tracked prostate cancer mortality in both study arms. At the median follow-up of nine years, researchers reported that PSA screening resulted in a 20% reduction in prostate cancer mortality!12

A study from the Göteborg center, one of the seven participating centers in this study, found that men aged 50 to 64 years of age who had a PSA screening every other year had a 44% reduced mortality risk from prostate cancer. The center used a PSA cutoff of 2.5 ng/mL to 3.0 ng/mL. Men with these cutoff PSA levels and higher were referred for additional testing, including a digital rectal exam, transrectal ultrasound, and prostate biopsy.13

Although it’s too late to help the tens of thousands of men who likely skipped PSA screening, we are grateful the USPSTF is slowly grappling with the well-documented issues in its original guidelines by issuing the new draft recommendations.14

The issue was further complicated by results from a study published in the New England Journal of Medicinein 2016. This trial followed 1,643 men for a decade, each with prostate cancer that was first detected by PSA screening, to see which of the most popular treatment techniques was most effective, including “active waiting” and monitoring the disease, surgery to remove the prostate gland, or external radiation beam therapy to treat the cancer. While the prostate-cancer-specific survival rate was high (>98%) in all three groups, researchers found that men in the “active waiting” group were more likely to progress to metastatic disease, and about half of them needed surgery or radiation therapy within the 10-year study period.15

These results suggest that men benefit from early detection and early treatment of prostate cancer.

Please note that Life Extension does not recommend “watchful or active waiting” in the presence of high PSA and/or low-grade prostate cancer. We instead advise men to follow an aggressive “active surveillance” program that involves an anticancer diet along with specific drugs and nutrients that may enable early-stage disease to be contained.

Rise in Metastatic Cancer Rates

While various agencies continue to issue contradictory and confusing advice, men across the country have paid the price. In late 2016, a research group from Northwestern Medicine released a stunning and tragic finding: diagnoses of metastatic prostate cancer, the worst type, climbed an unbelievable 72% between 2004 and 2013.16

To reach these findings, the group studied a database of more than three-quarters of a million men in the National Cancer Data Base. What they found should alarm any man who skips his PSA screening.

“The fact that men in 2013 who presented with metastatic disease had much higher PSAs than similar men in 2004 hints that more aggressive disease is on the rise,”17 said study author Dr. Edward Schaeffer, chair of urology at Northwestern University Feinberg School of Medicine and Northwestern Medicine.

“One hypothesis is the disease has become more aggressive, regardless of the change in screening,” said Dr. Schaeffer. “The other idea is since screening guidelines have become more lax, when men do get diagnosed, it’s at a more advanced stage of disease. Probably both are true. We don’t know for sure but this is the focus of our current work.”17

This makes treatment more difficult, and it’s exactly the situation Ben Stiller would have faced if his forward-thinking doctor hadn’t established a PSA baseline early on and tracked it, allowing him to discover Stiller’s troubling increase in PSA levels over time and recommend the movie star for further evaluation and surgery.

It’s important to note that the increase in metastatic, aggressive prostate cancer almost perfectly aligns with the trend away from PSA screening that culminated with the USPSTF 2012 recommendation against any PSA screening.

Prostate Cancer Survivors Due to Early Detection

Name Year Successfully Treated
Robert De Niro 2003 at age 60
John Kerry 2003 at age 60
Rudy Giuliani 2000 at age 56
Robert Goulet 1993 at age 60
Colin Powell 2003 at age 66
Michael Milken 1993 at age 46

Stiller’s Happy Ending

The main concern with PSA screening is the potential for overdiagnosis and unnecessary treatment. These are real concerns—PSA screening frequently returns “false positives,” which are stressful for the patients involved and result in unnecessary biopsies and additional tests.18

We recommends regular, inexpensive PSA screening to establish a baseline and follow PSA numbers over time. If your PSA level rises above 1.0 ng/mL, there are natural and safe measures you can take to reduce it. Further evaluation may be necessary if your PSA continues to rise over time.

In fact, this is exactly the course Stiller followed, and today he’s alive and grateful for it.

“The bottom line for me: I was lucky enough to have a doctor who gave me what they call a ‘baseline’ PSA test when I was about 46,” he wrote in Medium, a popular blogging platform. “My doctor watched my PSA tests rise for over a year and a half, testing me every six months…I think men over the age of 40 should have the opportunity to discuss the test with their doctor and learn about it, so they can have the chance to be screened.”19

More recently, two years after his diagnosis and treatment, Stiller went public with his experience with an interview with Matt Lauer on the Today show, alongside Dr. Schaeffer. While reporting that he wasn’t experiencing any of the major complications of prostate surgery, Stiller gave a simple reason for going public. He wanted to educate as many men as possible about their options when it came to PSA screening.

“It’s a whole new world,” Stiller said. “You need to educate yourself.”

We at Life Extension commend Bernard M. Kruger, M.D. for having the foresight to test Ben Stiller’s PSA blood levels despite conventional “authorities” advising against PSA screening.

Written By Jon Vanzile

Article Source: http://www.lifeextension.com/Magazine/2017/9/Ben-Stiller-Advocates-Prostate-Cancer-Screening/Page-01

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Low Plasma Testosterone Is Associated With Elevated Cardiovascular Disease Biomarkers

Leave a comment

BACKGROUND:

The relation between testosterone (T) plasma concentration and cardiovascular (CV) risk is unclear, with evidence supporting increased risk in men with low and high T levels. Few studies have assessed CV risk as a function of plasma T levels using objective biomarkers.

AIM:

To determine the relation between T levels and high-sensitivity CV risk biomarkers.

METHODS:

Ten thousand forty-one male patients were identified in the database of a commercial clinical laboratory performing biomarker testing. Patients were grouped by total T concentration and associations with the following biomarkers were determined: cardiac troponin I (cTnI), endothelin-1 (ET-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-17A, N-terminal pro-B-type natriuretic peptide (NTproBNP), high-density lipoprotein (HDL) cholesterol, high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and leptin.

OUTCOMES:

Association of CV risk markers with levels of T in men.

RESULTS:

The median age of the cohort was 58 years (interquartile range = 48-68), and the median plasma T level was 420 ng/dL (interquartile range = 304-565); T levels did not vary with patient age. An inverse relation between plasma T levels and CV risk was observed for 9 of 10 CV markers: cTnI, ET-1, IL-6, TNF-α, NTproBNP, HDL cholesterol, hs-CRP, HbA1c, and leptin. Even after adjusting for age, body mass index, HbA1c, hs-CRP, and HDL cholesterol levels, the CV markers IL-6, ET-1, NTproBNP, and leptin were significantly associated with a T level lower than 250 ng/dL.

CLINICAL IMPLICATIONS:

Men with low T levels could be at increased risk for increased CV disease as seen by increased CV risk markers.

STRENGTH AND LIMITATIONS:

This study was performed in a group of 10,041 men and is the first study to examine CV risk associated with circulating T levels using a large panel of 10 objective biomarkers. This study is limited by an absence of clinical data indicating whether men had pre-existing CV disease or other CV risk factors.

CONCLUSION:

Men with low plasma T levels exhibit increases in CV risk markers, consistent with a potential increased risk of CV disease. Pastuszak AW, Kohn TP, Estis J, Lipshultz LI. Low Plasma Testosterone Is Associated With Elevated Cardiovascular Disease Biomarkers. J Sex Med 2017;XX:XXX-XXX.

Article Source: https://www.ncbi.nlm.nih.gov/pubmed/28757119

 

“The Greatest Health of Your Life”℠

Boston Testosterone Partners
National Testosterone Restoration for Men
Wellness & Preventative Medicine

Older Entries